What It Measures
This test measures the ratio of albumin (a protein made by the liver that maintains fluid balance and transports substances) to globulins (a group of proteins including antibodies and enzymes involved in immune function, clotting, and inflammation). The ratio reflects the balance between these two major protein groups in your blood serum.
The Albumin/Globulin (A/G) ratio compares the levels of albumin to globulin proteins in the blood. It is a key indicator of liver function, kidney health, and immune system activity, and abnormal values can signal chronic disease, inflammation, or malignancy.
Current Value
What High Means
A high A/G ratio is relatively uncommon and typically indicates underproduction of globulins. This can be seen in immunodeficiency conditions (such as certain genetic immune disorders), leukemia, or conditions where immunoglobulin production is suppressed. It may also occur with high-dose corticosteroid use or hypothyroidism.
Possible Symptoms
A high A/G ratio is often asymptomatic. In cases of immunodeficiency: frequent infections, slow wound healing, fatigue. In hypothyroidism: weight gain, cold intolerance, fatigue, dry skin.
What Low Means
A low A/G ratio suggests either overproduction of globulins or underproduction of albumin (or both). Common causes include liver disease (cirrhosis, hepatitis), kidney disease (nephrotic syndrome where albumin is lost in urine), chronic inflammation, autoimmune diseases (lupus, rheumatoid arthritis), multiple myeloma and other plasma cell disorders, malnutrition, and chronic infections.
Possible Symptoms
Edema/swelling (especially in legs and abdomen due to low albumin), fatigue, weakness, unexplained weight loss, frequent infections, foamy urine (if kidney-related), jaundice (if liver-related), bone pain (if myeloma-related), abdominal distension/ascites.
Risk Factors
Liver disease (cirrhosis, hepatitis), kidney disease (nephrotic syndrome), multiple myeloma, chronic inflammatory conditions, autoimmune diseases (lupus, rheumatoid arthritis), malnutrition/malabsorption, chronic infections, immunodeficiency disorders, certain cancers (lymphoma, leukemia).
Actionable Advice
Supplements
- •N-Acetyl Cysteine (NAC)
- •Milk Thistle (Silymarin)
- •Whey Protein
- •Vitamin D3
- •Zinc
- •Omega-3 Fish Oil
- •Curcumin/Turmeric
- •Glutamine
- •B-Complex Vitamins
- •Collagen Peptides
Diet & Lifestyle
- •Consume adequate high-quality protein (0.7-1g per pound of body weight) from diverse sources
- •Limit alcohol consumption to protect liver function
- •Stay well-hydrated to maintain accurate protein measurements
- •Address chronic inflammation through anti-inflammatory diet (Mediterranean-style)
- •Get regular moderate exercise to support liver and immune health
- •Maintain healthy body weight to reduce liver fat accumulation
- •Manage stress through meditation, sleep hygiene, and recovery practices
- •Get 7-9 hours of quality sleep to support protein synthesis and immune regulation
- •Avoid processed foods and excess sugar which contribute to liver stress
- •Regular health screenings to catch liver or kidney issues early
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Historical Trend
Related Biomarkers
Resources & Studies
All Readings
| Date | Value | Change |
|---|---|---|
| 2025-08-25 | 1.5 - | +0.5 |
| 2025-06-27 | 1 - | — |