What It Measures
The blood level of homocysteine, a sulfur-containing amino acid that requires B vitamins for proper metabolism.
Homocysteine is an amino acid produced during methionine metabolism. Elevated levels damage blood vessels and are an independent risk factor for cardiovascular disease.
Current Value
What High Means
Elevated homocysteine (hyperhomocysteinemia) damages endothelial lining of blood vessels, promotes clotting, and increases risk of heart attack, stroke, and dementia. Often caused by B vitamin deficiency or MTHFR gene variants.
Possible Symptoms
Usually none until a cardiovascular event. May contribute to fatigue and cognitive decline.
What Low Means
Low homocysteine is generally healthy and indicates adequate B vitamin status and methylation.
Possible Symptoms
None
Risk Factors
Cardiovascular disease, stroke, dementia, blood clots, osteoporosis
Actionable Advice
Supplements
- •Methylfolate (5-MTHF)
- •Methylcobalamin (B12)
- •Vitamin B6 (P5P)
- •TMG (trimethylglycine/betaine)
- •Riboflavin (B2)
Diet & Lifestyle
- •Get adequate B vitamins through diet (leafy greens, eggs, meat)
- •Consider MTHFR genetic testing
- •Use methylated B vitamins if MTHFR positive
- •Regular exercise
- •Limit excessive coffee and alcohol
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Historical Trend
Related Biomarkers
Resources & Studies
All Readings
| Date | Value | Change |
|---|---|---|
| 2026-01-28 | 10.8 umol/L | 0.0 |
| 2025-08-25 | 10.8 umol/L | — |