What It Measures
The percentage of transferrin binding sites occupied by iron, calculated as (serum iron / TIBC) × 100.
Iron saturation measures what percentage of transferrin (the iron transport protein) is bound to iron. It helps differentiate types of iron disorders.
Current Value
14%
Reference Range: 20 – 50 %(standard)
Optimal Range: 25 – 35 %(Function Health, LabCorp, Quest Diagnostics)
+2.0 (+16.7%) from previous test
20 %Optimal: 25–3550 %
What High Means
High iron saturation (>45%) strongly suggests iron overload and is a key screening marker for hemochromatosis.
Possible Symptoms
Same as iron overload
What Low Means
Low iron saturation (<20%) indicates iron deficiency or chronic disease-related anemia.
Possible Symptoms
Same as iron deficiency
Risk Factors
Hemochromatosis screening (high), iron deficiency (low)
Actionable Advice
Supplements
- •Iron bisglycinate (if low)
- •Vitamin C (if low)
Diet & Lifestyle
- •Most reliable iron overload screening test
- •If >45%, test HFE gene for hemochromatosis
- •Blood donation to manage iron overload
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Historical Trend
Reference
Optimal
Related Biomarkers
Last researched Feb 14, 2026
All Readings
| Date | Value | Change |
|---|---|---|
| 2026-01-28 | 14 % | +2.0 |
| 2025-08-25 | 12 % | — |