What It Measures
The blood level of SHBG protein, which determines how much testosterone and estradiol are free (bioavailable) vs. bound.
SHBG is a protein produced by the liver that binds and transports sex hormones (testosterone, estradiol). It regulates the bioavailability of these hormones.
Current Value
What High Means
High SHBG reduces free testosterone, potentially causing low-T symptoms even when total testosterone is normal. Can be elevated by aging, hyperthyroidism, liver disease, or estrogen.
Possible Symptoms
Low libido, fatigue, ED (due to reduced free T)
What Low Means
Low SHBG increases free testosterone but may indicate insulin resistance, metabolic syndrome, hypothyroidism, or PCOS (in women).
Possible Symptoms
May contribute to acne, hair loss (excess free androgens)
Risk Factors
Hypogonadal symptoms when high; metabolic syndrome indicator when low
Actionable Advice
Supplements
- •Boron (may lower SHBG)
- •Stinging nettle root
Diet & Lifestyle
- •Address underlying causes (thyroid, liver, insulin resistance)
- •Maintain healthy body composition
- •Adequate protein intake
- •Limit excessive alcohol
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Historical Trend
Related Biomarkers
All Readings
| Date | Value | Change |
|---|---|---|
| 2026-01-28 | 30 nmol/L | -1.6 |
| 2025-09-18 | 31.64 nmol/L | +1.6 |
| 2025-08-25 | 30 nmol/L | +15.9 |
| 2025-07-31 | 14.07 nmol/L | -4.9 |
| 2025-06-27 | 18.97 nmol/L | — |