What It Measures
This test measures the blood level of DHEA-S, a hormone produced by the adrenal glands that serves as a building block for sex hormones (androgens and estrogens). Because DHEA-S has a long half-life and stable blood levels throughout the day, it is the preferred measure of adrenal androgen production.
DHEA-S is the sulfated form of DHEA, the most abundant circulating steroid hormone produced primarily by the adrenal glands. It serves as a precursor to both testosterone and estrogen, and its levels naturally decline with age, making it a key marker of adrenal function, biological aging, and hormonal vitality.
Current Value
What High Means
Elevated DHEA-S may indicate adrenal hyperplasia (such as congenital adrenal hyperplasia), adrenal tumors (adenoma or carcinoma), polycystic ovary syndrome (PCOS) in women, Cushing's disease, or exogenous DHEA supplementation. In women, excess DHEA-S can drive androgenic symptoms like hirsutism, acne, and menstrual irregularity. Very high levels warrant investigation for adrenal neoplasm.
Possible Symptoms
Acne, oily skin, hirsutism (excess hair growth in women), hair thinning or male-pattern baldness, menstrual irregularity, deepening voice in women, aggression or irritability, weight gain (particularly abdominal)
What Low Means
Low DHEA-S is associated with adrenal insufficiency (Addison's disease), hypopituitarism, chronic stress and HPA axis dysfunction, aging (levels peak in the mid-20s and decline ~2-3% per year thereafter), chronic illness, and long-term glucocorticoid use. Low levels are linked to increased cardiovascular risk, reduced immune function, decreased bone density, cognitive decline, depression, and fatigue.
Possible Symptoms
Chronic fatigue, decreased libido, depression or low mood, poor stress tolerance, brain fog and memory issues, decreased muscle mass, joint pain, dry skin and eyes, reduced immune resilience, bone loss, difficulty recovering from exercise
Risk Factors
Cardiovascular disease, osteoporosis, cognitive decline and Alzheimer's disease, depression, metabolic syndrome, type 2 diabetes, autoimmune conditions (lupus), chronic fatigue syndrome, reduced immune function, sarcopenia, accelerated aging
Actionable Advice
Supplements
- •DHEA (micronized, 10-50mg/day under medical supervision)
- •7-Keto DHEA
- •Vitamin D3
- •Magnesium glycinate
- •Zinc
- •Vitamin B6 (P5P)
- •Ashwagandha (KSM-66)
- •Rhodiola rosea
- •Pregnenolone
- •Fish oil (omega-3)
- •Vitamin C
Diet & Lifestyle
- •Prioritize 7-9 hours of quality sleep to support adrenal recovery
- •Practice stress management (meditation, breathwork, yoga) to reduce cortisol-driven DHEA depletion
- •Engage in regular resistance training — shown to support healthy DHEA-S levels
- •Maintain a healthy body weight — obesity is associated with dysregulated adrenal hormones
- •Reduce chronic stressors and avoid overtraining, which can suppress adrenal output
- •Limit alcohol and caffeine, both of which can impair adrenal function
- •Eat a nutrient-dense diet rich in healthy fats, zinc, magnesium, and B vitamins
- •Consider intermittent fasting, which may support hormonal optimization
- •Get regular sun exposure or supplement vitamin D, which supports steroidogenesis
- •Avoid long-term corticosteroid use when possible, as it suppresses DHEA production
Ask AI
Ask questions about your DHEA Sulfate results, trends, and what you can do to optimize.
Only one data point — trend chart will appear after multiple tests.
Related Biomarkers
Resources & Studies
All Readings
| Date | Value | Change |
|---|---|---|
| 2026-01-28 | 96 mcg/dL | — |